Artichoke Extracts – The Amazing Nootropic Anti-oxidant (Luteolin)

Written by David Gracey

Artichoke Extracts Quick Summary

Also Known As:
Cynara Cardunculus, Luteolol, Digitoflavone, Flacitran, Luteoline,2-(3,4-Dihydroxyphenyl)-5,7-dihydroxy-4H-1-benzopyran-4-one
Helps With:
An antioxidant used in traditional Chinese medicine that promotes synaptic plasticity, mental states, and enhanced memory skills
500-2000 mg of Artichoke extracts can be taken daily, divided into 2-3 increments.
Generally less than 5 hours, but in some cases up to 9 hours

According to wikipedia: Luteolin is a flavone, a type of flavonoid, with a yellow crystalline appearance.  It can function as either an antioxidant or a pro-oxidant and plants rich in luteolin have been used in Chinese traditional medicine.

‘Eat your greens’ holds a lot more wisdom than one could have ever imagined!

Artichokes have a lot of health benefits, most of which benefit the brain as well!

Artichokes are nature’s very own nootropic veggie!  Artichoke extracts amplify the effectiveness!

What Is An Artichoke Extract?

Artichokes are plants, this we know.

Their botanical name is Cynara Cardunculus – fancy!

Its stem and roots are of particular importance; they contribute to a variety of medicines and are also used for formulating artichoke extracts.

Extracts are a concentrated version of the source that they are derived from.

Artichoke extracts are rich in Cynarins; a component that equips these plants with nootropic potential.

Once they are concentrated, their structure is enriched with Luteolins – a potent antioxidant.

How Do Artichoke Extracts Work?

These babies are Phosphodiesterase-4 (PDE-4) inhibitors, an enzyme that degrades cAMP.

While this enzyme is necessary for the regulation of inflammatory levels, an excess could lead to a disruption in the balance of inflammatory mediators.

PDE-4 in excess aggravates inflammation and also lowers cAMP levels.

cAMP is a secondary messenger of the cell that not only regulates the transport of glucose but also encourages Long Term Potentiation.

Long Term Potentiation is a process whereby the neuronal machinery is strengthened by repeated and long-lasting communication between the synapses.

By inhibiting PDE-4, cAMPs increase!

Hence promoting synaptic plasticity, mental states, and memory skills!

The Role Of Luteolin In Artichokes

Luteolin is categorized as a tetrahydroxyflavone that acts as a free radical scavenger.

However, it can not be absorbed by the intestines unless a bioflavonoid accompanies it.

And that’s where Artichokes come in!

Narirutin and Apigenin-7-rutinoside are two compounds found in artichokes that allow Luteolin to get absorbed and unleash its potential role in the body.

It is thus advised to use Luteolin enriched artichokes instead of pure Luteolin to get the best of both worlds!

Backing Claims With Science – Proof That Artichoke Extracts Work!

Artichoke extracts have been termed as a herbal remedy for hepatocellular and cardiovascular disorders.

They also help aid digestion.

But what interests me the most about this extract is its ability to induce long term potentiation!

To be specific, it targets areas of behavioral memory and refines it by encouraging hippocampal plasticity.

And thus enhances memory strength.

They are also powered by a unique composition of antioxidants that are purifying in nature!

PDE-4 inhibition contributes to a rise in dopamine neurotransmission; a process that helps alleviate symptoms of schizophrenia whilst improving memory.

Now let’s talk about the role of Luteolin.

Luteolin downsizes inflammatory responses by decreasing the production of IL-6, an inflammatory mediator.

Inflammation may also be mediated by the microglia (cells of the brain and spinal cord) which often leads to a decline in cognitive function.

Luteolin inhibits the microglia when they are propagating such events, hence preventing neurodegeneration.

What Is The Recommended Dosage Of Artichoke Extracts?

500-2000 mg of Artichoke extracts can be taken daily, divided into 2-3 increments.

Around 600 mg waives off symptoms of dyspepsia and indigestion whereas more than up to 900 mg inhibits the PDE-4 enzyme.

More than 900 mg helps tone down cholesterol levels.

You may take this extract in the morning but the dosage should be kept low!

I’ll tell you why in the adverse effects section below – it’s interesting so stay tuned!

What Are The Benefits Of Taking Artichoke Extracts As A Nootropic?

Enhanced Memory

Thanks to the synaptic plasticity effect.

Antioxidant Replenishment

Due to the aggressive free radical hunting action of Luteolin.

Lowers LDL Cholesterol

The bad cholesterol!

Enhances Cognition

By inhibiting the action of PDE-4.

Reduces Inflammation

By lowering Interleukin-6 levels.

Are There Any Side Effects Of Artichoke Extracts?

Artichoke extracts might make you drowsy and sleepy!

Because of the upregulation of cAMP, the Acetylcholinesterase enzyme becomes more active.

Acetylcholinesterase is responsible for breaking down Acetylcholine.

This reduces the levels of Acetylcholine in the brain, hence induces sleepiness.

And that is why you should be taking this preferably at night!

Common Side Effects of Artichoke Extracts Include:
Gastrointestinal Disturbances
Gas or Bloating

Are Artichoke Extracts Safe? – Warnings & Interactions!

Artichokes are a part of many diets and are considered very much safe.

However, there are a set of interactions and warnings that are associated with its use.

Artichoke Extracts Safety Precautions Include:

  • Pregnant or lactating females should avoid the use of Artichoke extracts
  • Individuals suffering from bile duct obstruction or gallstones should not consume artichokes since their use is associated with increased bile production
  • Other gallbladder contractions
  • Individuals that are allergic to ragweed should avoid Artichoke extracts

Vinpocetine Drug Interactions Include:

There are no known interactions of this extract as of yet that I could find.

Where Can I Buy Artichoke Extracts?

Artichoke extracts are abundantly available online and in stores without the need for any prescription.

You can also find these extracts on Amazon.

Stacking Artichoke Extract For Synergy!



As already mentioned above, artichoke extracts may induce sleepiness due to low Acetylcholine levels.

ALCAR can amp up these levels to avoid this side effect!

And you may even supplement this together in the morning in that case!

See our Full Article on Alcar Here

With Forskolin

Forskolin boosts cAMP levels and this would allow you to lower the dosage of Artichoke extracts.

This happens to be one of the most hyped stacks when it comes to artichoke extracts!

With Caffeine, Coffee, Or Green Tea

For the same reason as that of ALCAR.

To avoid sleepiness and get a boost of wakefulness!

With Phenylalanine

Phenylalanine is an essential amino acid that can boost the production of Dopamine, Tyrosine, and adrenaline.

It forms a good synergy with artichoke extracts and can improve the mood.

And also contribute to sharper memory skills.


With Milk Thistle

The two of them together make a kick-ass liver cleansing duo.

This stack is more effective for liver detoxification rather than nootropic benefits.

FAQ: Are artichoke extracts good for the gall bladder?

Artichoke extracts encourage bile flow and are hence good for maintaining the health of the gall bladder.

However, those with gall bladder stones or obstructions should avoid the use of artichoke extracts as they might aggravate the symptoms of such conditions.

My Final Thoughts About Artichoke Extracts as a Nootropic… (Cynara Cardunculus)

Artichokes should be a part of our diets but supplementing them is not a bad idea either.

They impart some fruitful benefits, undoubtedly.

But if you’re looking for heavy nootropic potential, then this option might weigh down on the scale a bit.

Despite having nootropic properties, this extract is more of a liver cleanser and intestinal health booster.  Overall, it is absolutely wonderful for overall health and wellbeing!

It’s Very Affordable! (As Low as 7 Cents per Serving!!!)

Best of all, artichoke extract supplements are very affordable!

So why not give it a shot!  >> Click here to compare the top Artichoke Extracts

About David:

Hey! I’m so glad you’re here. My name is David Gracey. I am a cognitive brain function researcher, avid biohacker, and self-proclaimed nootropic junkie of sorts! (And, yes, a bit of a nerd as well...) I created this website as an outlet to share my passion for self improvement and cognitive brain enhancement. Got questions? Shoot me a message!










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About David Gracey

About David Gracey

Founder of

Hey! My name is David Gracey.  I am the brain child of and a Cognitive Brain Function Researcher, Avid Biohacker, Lucid Dreamer, Morning Ritual Master, and Self-Proclaimed Nootropic Junkie of Sorts! 

In other words, I am completely obsessed with anything and everything related to cognitive brain enhancement! 

Whether it's nootropics supplements, challenging brain puzzles, or even meditation techniques, chances are, I've tried it!  This website is my outlet to give back and share what I've learned in the past 15+ years in this field of study. 

You Can Read my Other Posts Here:  David Gracey's Articles