Also Known As:
Centrophenoxine has long been credited for its memory-boosting properties and similarities with the brain’s chief neurotransmitter ‘Acetylcholine’.
But there’s a lot more to this nootropic! Let’s find out!
Centrophenoxine Review – What is It Exactly?
Centrophenoxine, also known as Meclofenoxate, is a cholinergic supplement that has undergone rigorous testing over the decades.
Its development in France circa 1959 by the French National Scientific Research Center catered to the needs of Alzheimer’s patients that struggled from cognitive imbalance and loss of memory.
It is known in the market by the brand name of Lucidril.
The nootropic properties of Centrophenoxine have necessitated its use for memory disabling disorders.
Centrophenoxine is made up of two esters, one of which is DMAE – another renowned nootropic!
Individuals are said to have performed better in memory tests when dosing on this nootropic!
Backing Claims With Scientific Research – Proof That Centrophenoxine Works!
Mice demonstrated superior performance in the T-maze memory test when dosed with Centrophenoxine for 3 months.
Compared to the counterpart group of mice that did not receive Centrophenoxine, the former group resolved hurdles with more ease and also showed a decrease in neuronal lipofuscin.
Lipofuscin is a ‘wear and tear’ pigment and its deposition in the brain increases with age!
Centrophenoxine aids the process of Lipofuscinogenesis.
Along with boosting memory amongst old aged individuals, this nootropic also showed an increase in mental alertness!
The synergy between Centrophenoxine and Rhodiola Rosea has been observed in a study where they both worked in harmony to promote learning and memory, even when the brain had been impaired by shock!
Centrophenoxine also boosts blood flow.
It helps alleviate the effects of chronic cerebral ischemia which leads to significant cognitive decline and has henceforth been declared useful for dementia.
This nootropic element is neuroprotective in nature and may also boost cognition.
It decreases Acetylcholinesterase’s activity, an enzyme that decreases Acetylcholine levels by breaking it down.
The unique mechanism of Centrophenoxine allows it to prompt antioxidant enzymes to perform better and also double in quantity – a process that often declines with age.
And this mechanism comes in handy for alleviating the symptoms of Parkinson’s disease.
Similarly, it also promotes the action of anti-tumor agents indirectly!
In other words, Centrophenoxine acts as a potentiating element in the body!
Amongst many of its functions, Centrophenoxine is also credited for its anti-aging activity.
It mainly does this by upscaling the synaptic plasticity of the neuronal machinery!
Centrophenoxine may also elevate the mood by acting as an anxiolytic!
What Is The Recommended Dosage Of Centrophenoxine?
250-1000 mg of Centrophenoxine is considered safe and effective. (In some cases up to 3000mg per day is used)
This can be divided into increments of two or three and administered throughout the day.
One of the benefits of this nootropic is that it is tolerated very well even in higher doses!
However, I would still recommend starting off with the smallest possible dose and gradually build your way through to bypass unprecedented side effects.
Due to its fat-soluble nature, it is best to take Centrophenoxine with breakfast or a meal – preferably in the morning.
What Are The Benefits Of Taking Centrophenoxine As A Nootropic?
Boosted Memory And Cognitive Function
Due to an increase in Acetylcholine!
This nootropic not only aids the formation and storage of memory but also leads to superior learning and recall.
It also increases synaptic plasticity.
Enhances Mental Alertness
As studies have shown!
This could be attributed to its antioxidant promoting properties.
Decreases Lipofuscin Deposits
And hence retards the aging process.
By boosting the antioxidant activity.
Are There Any Side Effects Of Centrophenoxine?
Common side effects of taking centrophenoxine include:
- Muscle spasms/tremors
Is Centrophenoxine Safe? – Warnings & Interactions!
Our centrophenoxine review determination as far as safety goes, is that it’s absolutely safe to consume and is hence used as a dietary supplement.
However, overdosage may result in a few adverse effects.
I also recommend you follow this set of precautions before administering this nootropic:
- Always consult your doctor before consumption of ANY nootropic, especially if you are on medication or have been diagnosed with a certain diseases/disorder
- Pregnant or lactating females should avoid the use of Centrophenoxine
- Individuals below 18 years of age should also avoid the use of Centrophenoxine OR consult a physician before administering this nootropic
As of yet, there are no known interactions of Centrophenoxine.
Where Can I Buy Centrophenoxine?
Luckily, this nootropic is available as an over-the-counter supplement in the USA and Canada.
However, in some regions of Europe and Japan, one might need a prescription to purchase Centrophenoxine.
You can buy centrophenoxine online here. This is by far the best quality / cheapest option for buying centrophenoxine online in my opinion.
However, you can also purchase Centrophenoxine on Amazon. >> Click here to compare options on Amazon.
The Art Of Stacking Centrophenoxine for Synergy!
Racetams are categorized as nootropics that boost memory skills and enable superior learning.
Pairing them with Centrophenoxine will double the performance of each element. It is reported that Centrophenoxine potentiates the effects of racetams!
Aniracetam is commonly used together with Centrophenoxine to help alleviate the symptoms of memory disabling disorders.
You can purchase racetams online here.
Interestingly, this is a derivative of the infamous racetams that we just discussed above.
However, Noopept delivers superior performance and hence superior results as a nootropic.
The memory-boosting abilities of Noopept and Centrophenoxine can be availed by both adults and old aged individuals!
This stack will also propagate efficient learning!
Where I Personally Buy Noopept:
This is beacause they provide a real certificate of analysis (proving it’s the real deal), and has a ton of awesome reviews and feedback. It’s also my personal choice for buying noopept.
They sell authentic and safe Noopept so you can feel at ease. (Plus its actually super affordable!)
* Not only that, they sell all forms of it, including: Powder, Capsules, & Sublingual Solution
With Modafinil Or Adrafinil:
If you wish to spice up your memory and also enjoy a kick of wakefulness, then this is the stack for you!
Modafinil, Adrafinil, and Armodafinil have long been used for sleeping disorders such as narcolepsy.
And they have now been recognized as potential nootropics for daily use!
Before buying any of these 3 nootropics, I suggest reading my detailed Article on the differences between Modafinil, Adrafinil and Armodafinil Here!
Some Products That Contain Centrophenoxine In Their Formula!
As far as my research is concerned, Centrophenoxine has not yet been formulated as a nootropic stack.
However, you can still create your own stack by using individually sold Centrophenoxine!
They have great value (cheaper than almost all other brands) plus, they have amazing quality!
FAQ – Frequently Asked Questions Related to Centrophenoxine:
Centrophenoxine vs. DMAE – What Is The Difference Between Centrophenoxine And DMAE?
Centrophenoxine is said to be sprouted from DMAE – hence the latter being a part of Centrophenoxine’s structure.
DMAE is also a nootropic but can not be used to the best of its ability since it can not pass the blood-brain barrier.
This problem is resolved with the use of its derivative Centrophenoxine which easily crosses the barrier to exerts its nootropic effects in the brain.
What Is A Cholinergic?
Any agent that can trigger the release of Acetylcholine or Butyrylcholine is considered a cholinergic.
Agents that mimic the actions of the above two neurotransmitters by adhering to cholinergic receptors are also considered a part of this family.
What Is Centrophenoxine Used For?
It was originally designated to treat dementia but due to its safe nature, it is now becoming a part of nutritional supplements for daily use.
Can Centrophenoxine Cause Depression?
Centrophenoxine is reported to decrease the symptoms of depression.
However, depression is also cited as a side effect of Centrophenoxine that may arise from misuse or if an individual is struggling with a disorder.
It is therefore important to consult your doctor before administering any nootropic.
Centrophenoxine as a Nootropic Supplement: Final Thoughts…
Centrophenoxine is a great source of choline hence a credible memory-booster.
It might not be as strong or potent as its competitors in the nootropic industry, but it is definitely a great choice for those who are just commencing their nootropic journey!
One can avail maximum benefits of this nootropic by stacking, so consider adding centrophenoxine as part of your next nootropic stack!
Citations & References:
Nandy K. Centrophenoxine: effects on aging mammalian brain. J Am Geriatr Soc. 1978 Feb;26(2):74-81. doi: 10.1111/j.1532-5415.1978.tb02544.x. PMID: 342588.
Platel A, Porsolt RD. Habituation of exploratory activity in mice: a screening test for memory enhancing drugs. Psychopharmacology (Berl). 1982;78(4):346-52. doi: 10.1007/BF00433739. PMID: 6818597.
Liao Y, Wang R, Tang XC. Centrophenoxine improves chronic cerebral ischemia induced cognitive deficit and neuronal degeneration in rats. Acta Pharmacol Sin. 2004 Dec;25(12):1590-6. PMID: 15569402.
Herrschaft H, Gleim F, Duus P. The effect of centrophenoxine on regional cerebral blood flow in man (author’s transl). Dtsch Med Wochenschr. 1974 Aug 30;99(35):1707-14. English. doi: 10.1055/s-0028-1108035. PMID: 4605996.
Nandy K. Lipofuscinogenesis in mice early treated with centrophenoxine. Mech Ageing Dev. 1978 Aug;8(2):131-8. doi: 10.1016/0047-6374(78)90013-1. PMID: 357853.
Nehru B, Bhalla P, Garg A. Evidence for centrophenoxine as a protective drug in aluminium induced behavioral and biochemical alteration in rat brain. Mol Cell Biochem. 2006 Oct;290(1-2):33-42. doi: 10.1007/s11010-006-9125-7. Epub 2006 Sep 13. PMID: 16969689.
Nehru B, Bhalla P. Reversal of an aluminium induced alteration in redox status in different regions of rat brain by administration of centrophenoxine. Mol Cell Biochem. 2006 Oct;290(1-2):185-91. doi: 10.1007/s11010-006-9186-7. Epub 2006 Sep 13. PMID: 16969688.
Marcer D, Hopkins SM. The differential effects of meclofenoxate on memory loss in the elderly. Age Ageing. 1977 May;6(2):123-31. doi: 10.1093/ageing/6.2.123. PMID: 329662.
Lazarova MB, Petkov VD, Markovska VL, Petkov VV, Mosharrof A. Effects of meclofenoxate and Extr. Rhodiolae roseae L. on electroconvulsive shock-impaired learning and memory in rats. Methods Find Exp Clin Pharmacol. 1986 Sep;8(9):547-52. PMID: 3095599.
Oliver JE, Restell M. Serial testing in assessing the effect of meclofenoxate on patients with memory defects. Br J Psychiatry. 1967 Feb;113(495):219-22. doi: 10.1192/bjp.113.495.219. PMID: 4382246.
Roy D, Pathak DN, Singh R. Effect of centrophenoxine on the antioxidative enzymes in various regions of the aging rat brain. Exp Gerontol. 1983;18(3):185-97. doi: 10.1016/0531-5565(83)90031-1. PMID: 6416880.
Sladek NE. Potentiation of antitumor drug action by centrophenoxine: specificity. J Pharmacol Exp Ther. 1977 May;201(2):518-26. PMID: 323465.
Bhalla P, Nehru B. Modulatory effects of centrophenoxine on different regions of ageing rat brain. Exp Gerontol. 2005 Oct;40(10):801-6. doi: 10.1016/j.exger.2005.06.016. Epub 2005 Aug 31. PMID: 16137852.
Verma R, Nehru B. Effect of centrophenoxine against rotenone-induced oxidative stress in an animal model of Parkinson’s disease. Neurochem Int. 2009 Nov;55(6):369-75. doi: 10.1016/j.neuint.2009.04.001. Epub 2009 Apr 16. PMID: 19375462.
Dylewski DP, Nandy S, Nandy K. Effects of centrophenoxine on lipofuscin in the retinal pigment epithelium of old mice. Neurobiol Aging. 1983 Spring;4(1):89-95. doi: 10.1016/0197-4580(83)90059-3. PMID: 6410295.
Bertoni-Freddari C, Giuli C, Pieri C. The effect of acute and chronic centrophenoxine treatment on the synaptic plasticity of old rats. Arch Gerontol Geriatr. 1982 Dec;1(4):365-73. doi: 10.1016/0167-4943(82)90036-x. PMID: 6821145.
Petkov VD, Getova D, Mosharrof AH. A study of nootropic drugs for anti-anxiety action. Acta Physiol Pharmacol Bulg. 1987;13(4):25-30. PMID: 2896427.