D-Phenylalanine (DLPA) – Powerful Stress & Discomfort Reliever For Optimal Performance and High-Pressure Situations

Article by: David Gracey
What is DLPA D-Phenylalanine Supplement?
  • Do you need help gearing up and coping with stress in your life?

  • Are you struggling to work productively and finding everyday life challenging?

Many of life’s problems can cause stress, anxiety, or even depression. The feeling is sometimes overwhelming and gets the best of us.

Stress can have a devastating impact on your health. If left unaddressed, stress can cause serious illnesses later in life.

Hang on in there!

Some ways can help you beat stress and look at it directly in the eye.

No fear, no resentment.

The answer to your worries is DLPA supplements!

DLPA Supplements can help hardworking people to bring about an essential oomph in their performance!

I wouldn’t suggest going all out and losing your will to perform entirely, of course.

You must be aware that eating a balanced diet consisting of a variety of foods is key to good health and well-being.

What is a lesser-known fact is that, unfortunately, one group of nutrients is often found lacking in our diets: amino acids.

Are they important?

Do we really need them?

The short answer: We can’t do without them!

Amino acids are the building blocks for proteins, and proteins are the building blocks of life.

They’re crucial to repair damaged cells in your body and make new ones.

Your body needs amino acids in large amounts for optimal functioning. Meat, milk, eggs, nuts, whole grains, and fish are rich sources of amino acids.

By incorporating these foods into your diet, you can meet the daily protein requirement of your body.

There are three kinds of amino acids: essential, non-essential, and conditional amino acids.

Our subject of interest, phenylalanine, is an essential amino acid, and it means that the body cannot synthesize it on its own.

Therefore, we must get it from the foods we eat.

Not getting an adequate amount of d-phenylalanine from your diet could seriously wreck your mental health.

Low levels of this essential amino acid could lead to major depressive disorders.

If your dietary supply of phenylalanine is short, consider taking phenylalanine supplements.

What is DL-phenylalanine?

DLPA is often confused by the different forms of phenylalanine.   

The DLPA supplement consists of two forms of phenylalanine: L-phenylalanine and D-phenylalanine.

These are basically mirror images of the same amino acid but with different orientations.

L-phenylalanine plays an active role in the human body; it boosts the production of neurotransmitters and builds proteins and other critical molecules.

Being abundant in foods such as eggs, meat, dairy, and nuts, it can easily be incorporated into your diet.

D-phenylalanine is the synthetic form of phenylalanine. Your body can’t use it to build other molecules, but it can still affect your health.

DL-phenylalanine is a combination of two types of phenylalanine and provides some surprising benefits! It is easily available in the form of supplements.

If you suffer from mood swings or mild depression and are looking for a supplement to help you manage your mood, this is your wonder nootropic right here!

DLPA works in helping to alleviate symptoms of depression, reduce pain, and help eliminate brain fog!

According to Wikipedia:
DL-Phenylalanine (DLPA) is marketed as a nutritional supplement for its purported analgesic (sort of like black seed oil!) ;

and antidepressant activities. DL-Phenylalanine is a mixture of D-phenylalanine and L-phenylalanine.

What are the Benefits Provided by DLPA Supplements?

L-phenylalanine works great as a nootropic by facilitating the production of norepinephrine and dopamine.

Phenylalanine is converted into another amino acid, tyrosine, by our body.

It then employs tyrosine to synthesize the mood-boosting neurotransmitters norepinephrine and dopamine.

Low levels of these chemicals are often the culprits behind symptoms of depression.

Dopamine plays a significant role in our unique ability to think and plan.

It helps us learn, strive, focus, feel happiness and pleasure, and control our mood, among many others. Studies have shown that a boost in dopamine results in improved cognitive function.

Norepinephrine works as a stress hormone and a neurotransmitter.

In stressful situations, your body releases it into the bloodstream to help cope with it immediately.

It aids in bringing about a quick response by increasing heart rate, blood flow to the muscles, and glucose levels in the body.

As a neurotransmitter, norepinephrine enhances alertness and concentration and also has an impact on your mood.

D-phenylalanine has both antidepressant and analgesic properties.

It functions as an analgesic by inhibiting the breakdown of endorphins (the body’s natural painkillers).

By inhibiting their degradation, the effects of pain relief are prolonged. Thus, D-phenylalanine may be used to treat chronic pain conditions.

>> Shop and Compare DLPA Supplements Here!

DLPA may be used for treating substance abuse:

DLPA supplements have been used to treat withdrawal symptoms of alcohol abuse and have shown promising results.

May be used for treating vitiligo:
L-phenylalanine is also a precursor of melanin.

For this reason, it is widely used to treat the skin condition vitiligo by many dermatologists.

It may be used both orally and topically with UV exposure for maximum results.

Why do you need DLPA?

As you get older, your body is undergoing drastic changes.

Little tasks start to become sources of high friction. Concentrating on simple chores gets increasingly difficult.

It’s hard to remember where you placed your car keys or if you’ve had lunch. Your brain functions start to decline.

Forgetfulness settles in as a permanent guest.

Although these changes are common signs of aging, they can even occur because of poor lifestyle and dietary choices.

If you feel like you’re unable to function at your best or have trouble concentrating, this supplement contains all you need to bounce back on track!

Aging also leads to a decrease in catecholamines (dopamine and norepinephrine).

A decline in dopamine and norepinephrine levels inevitably leads to impaired motor and cognitive function.

There is also an increase in the degree of stress that one might experience with growing age.

Stress also harms your ability to focus and concentrate.

A shortened concentration span will leave you lingering on a straightforward task for hours.

Give these supplements a try and see how they work to defog your brain and get your life back in control!

DLPA Recommended Dosage:

You should consult with your physician to find the optimal dosage recommended for your personal needs.

The dosage is adjusted according to specific health conditions.

The generally recommended dosage of L-phenylalanine for cognitive benefit is 500mg thrice a week.

However, certain dosage guidelines have been established with the help of data gathered by clinical experience.

The guideline is as follows:

  • For chronic pain management: 1500-3000mg daily
  • For treating depression: 150-200mg daily for 2-4 weeks
  • For treatment of ADHD: increasing dose from 150-1200mg daily for 2 weeks
  • For treatment of vitiligo: 50-100mg per day, along with ultraviolet light

Are There any Side Effects Associated with DLPA Supplements?

According to the data collected from many clinical trials, DLPA is safe to use in general for most people.

However, there is an exception to this general rule.

*People suffering from a condition known as phenylketonuria
NOT take this supplement!


  • Phenylketonuria.
    People with PKU (phenylketonuria)- a rare metabolic disorder- should steer clear of DLPA supplement use.  These individuals are unable to process phenylalanine efficiently.

    This causes phenylalanine to accumulate, subsequently causing irreversible brain damage, severe intellectual disability, and cognitive impairment.

  • Pregnant women.
    Due to a lack of clinical data, pregnant women should avoid the use of this supplement.

How Long Does it Take for DLPA to Work?

Although this depends on the condition that you are using this supplement for, it is observed that in most cases, DLPA starts to show results within two weeks!

Also, the effects of DLPA supplements start to fade out over time with long-term use.

Does DLPA Interact with Other Drugs?

Yes, be cautious and talk to your healthcare provider if you are someone taking any of the following medications:

Levodopa-for Parkinson’s Disease:

The drug L-dopa (used to treat Parkinson’s) reacts with DLPA supplement and impairs the transport of L-dopa to the brain. This can have serious consequences.

Monoamine Oxidase Inhibitors (MAOIs) – Used to Treat Depression:

This is a group of anti-depressant drugs consisting of isocarboxazid (Marplan), phenelzine (Nardil), and tranylcypromine sulfate (Parnate).

Supplementing with DLPA may cause a dangerous spike in blood pressure in people taking these drugs.

This sudden rise in blood pressure is called ‘hypertensive crisis’ and can have devastating consequences, such as a stroke or even a heart attack.

Due to this reason, individuals taking MAOI medications should refrain from any foods or supplements that contain phenylalanine.


Selegiline is a selective MAO inhibitor, widely used to treat Parkinson’s disease.

Taking it in conjunction with phenylalanine supplements increases the anti-depressant effects of phenylalanine.

Do not take this supplement if you are using selegiline medication.

Baclofen – For Muscle Spasms:

Phenylalanine may interfere with and reduce the absorption of baclofen medication.

Therefore, it is advised not to take this medication at mealtimes, especially if your diet is high in protein content.

It is also advised to refrain from using phenylalanine supplements when taking this medicine.

Neuroleptic Drugs:

L-phenylalanine may worsen some side effects related to the use of neuroleptic drugs (such as phenytoin, carbamazepine, valproic acid), especially tardive dyskinesia side effects.

Physicians advise against using it alongside these medications.

D-Phenylalanine Frequently Asked Questions – DLPA FAQ:

What is the best way to take DLPA?

It is most effective when taken on an empty stomach or at least one hour before mealtime.

Are there any supplements that I can take along with it to enhance its effects?

Absolutely. Taking DLPA alongside vitamins C and B6 helps maximize its absorption into your system!

What is the DLPA supplement used for?

This supplement is used to treat the following conditions:

  • Depression
  • Chronic pain
  • Osteoarthritis
  • Rheumatoid arthritis
  • Vitiligo
  • Decreases the symptoms of alcohol withdrawal

D-Phenylalanine DLPA – Final Thoughts…

DLPA is an essential amino acid that is crucial in the development and growth of the body.

It is also vital for the production of certain hormones and neurotransmitters.

Supplementing DLPA can provide an expansive array of benefits for both the mind and body.


Ready to give it a try?

>> Click here to view and compare  the top selling DLP supplements!

About David:

Hey! I’m so glad you’re here. My name is David Gracey. I am a cognitive brain function researcher, avid biohacker, and self-proclaimed nootropic junkie of sorts! (And, yes, a bit of a nerd as well...) I created this website as an outlet to share my passion for self improvement and cognitive brain enhancement. Got questions? Shoot me a message!










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